Article
A study on polymorphisms of elastin gene in Chinese Han patients with isolated systolic hypertension.
American journal of hypertension - 1 Jun 2009
Deng Liehua, Huang Rong, Chen Zhanyin, Wu Lei, Xu Ding-Li
Abstract excerpt
BACKGROUND: Elastin (ELN) is mainly located in the internal elastic lamina of large arteries. Degradation of ELN is expected to induce large vessel stiffness, which could lead to elderly systolic hypertension. Recent studies have shown that polymorphism of ELN is associated with stiffness of elastic arteries and elevated blood pressure; however, there are no further studies on isolated systolic hypertension...
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