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Article

Association of the TGF-beta receptor genes with abdominal aortic aneurysm.

European journal of human genetics : EJHG - 1 Feb 2010

Baas A F, Medic J, van 't Slot R, de Kovel C G, Zhernakova A, Geelkerken R H, Kranendonk S E, van Sterkenburg S M, Grobbee D E, Boll A P, Wijmenga C, Blankensteijn J D, Ruigrok Y M

Abstract excerpt

Abdominal aortic aneurysm (AAA) is a multifactorial condition. The transforming growth factor beta (TGF-beta) pathway regulates vascular remodeling and mutations in its receptor genes, TGFBR1 and TGFBR2, cause syndromes with thoracic aortic aneurysm (TAA). The TGF-beta pathway may be involved in aneurysm development in general. We performed an association study by analyzing all the common genetic variants in...

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Source

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Identifiers

PMID: 19672284
DOI: 10.1038/ejhg.2009.141
PMCID: PMC2987181

Genes

TGFBR1
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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