Article
Association of PPARgamma allelic variation, osteoprotegerin and abdominal aortic aneurysm.
Clinical endocrinology - 1 Jan 2010
Moran Corey S, Clancy Paula, Biros Erik, Blanco-Martin Bernardo, McCaskie Pamela, Palmer Lyle J, Coomans Danny, Norman Paul E, Golledge Jonathan
Abstract excerpt
OBJECTIVE: We have previously demonstrated high concentrations of the glycoprotein osteoprotegerin (OPG) in biopsies of abdominal aortic aneurysm (AAA), and demonstrated that ligation of the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) downregulates OPG in vitro and within a mouse model. The aims of this study were to assess the associations between circulating concentrations of...
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