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Article

ACE and TGFBR1 genes interact in influencing the susceptibility to abdominal aortic aneurysm.

Atherosclerosis - 1 Jan 2009

Lucarini Laura, Sticchi Elena, Sofi Francesco, Pratesi Giovanni, Pratesi Carlo, Pulli Raffaele, Gensini Gian Franco, Abbate Rosanna, Pepe Guglielmina, Fatini Cinzia

Abstract excerpt

A role of ACE I/D polymorphism in the pathogenesis of abdominal aortic aneurysm (AAA) has been demonstrated, possibly due to the effect of angiotensin II on vascular tissue remodelling. Angiotensin II exerts profibrogenic effects through the local induction of TGF-beta. Dysregulated TGF-beta signalling may result from mutations in TGFBR1 and TGFBR2 genes, thus resulting in degenerative changes in the vessel wall....

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Source

Identifiers

PMID: 18550062
DOI: 10.1016/j.atherosclerosis.2008.04.038

Genes

ACE
TGFBR1
CAD
TGFBR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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