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Article

The folding of an enzyme. IV. Structure of an intermediate in the refolding of barnase analysed by a protein engineering procedure.

Journal of molecular biology - 5 Apr 1992

Matouschek A, Serrano L, Fersht A R

Abstract excerpt

The pathway of refolding of barnase has been analysed by the protein engineering method using phi plots. The description comprises a folding intermediate, a major transition state (the unfolding transition state) and the fully folded structure. Over 40 mutations have been analysed in the different structural motifs, frequently with several probes in each region. Many of the mutations in this study give phi values...

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Identifiers

PMID: 1569559
DOI: 10.1016/0022-2836(92)90564-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The folding of an enzyme. IV. Structure of an intermediate in the refolding of barnase analysed by a protein engineering procedure.PMID 1569559Read ↗

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