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Article

Transition-states in protein folding kinetics: the structural interpretation of Phi values.

Journal of molecular biology - 2 Feb 2007

Weikl Thomas R, Dill Ken A

Abstract excerpt

Phi values are experimental measures of the effects of mutations on the folding kinetics of a protein. A central question is what structural information Phi values give about the transition-state of folding. Traditionally, a Phi value is interpreted as representing the "nativeness" of a mutated residue in the transition-state. However, this interpretation is often problematic. We present here a better structural...

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Source

Identifiers

PMID: 17141267
DOI: 10.1016/j.jmb.2006.10.082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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