Article
The kinetic pathway of folding of barnase.
Journal of molecular biology - 10 Oct 2003
Khan Faaizah, Chuang Jessica I, Gianni Stefano, Fersht Alan R
Abstract excerpt
To search for folding intermediates, we have examined the folding and unfolding kinetics of wild-type barnase and four representative mutants under a wide range of conditions that span two-state and multi-state kinetics. The choice of mutants and conditions provided in-built controls for artifacts that might distort the interpretation of kinetics, such as the non-linearity of kinetic and equilibrium data with...
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