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Article

Foldability of barnase mutants obtained by permutation of modules or secondary structure units.

Journal of molecular biology - 12 Mar 1999

Tsuji T, Yoshida K, Satoh A, Kohno T, Kobayashi K, Yanagawa H

Abstract excerpt

Modules, defined as stable, compact structure units in a globular protein, are good candidates for the construction of novel foldable proteins by permutation. Here we decomposed barnase into six modules (M1-M6) and constructed 23 barnase mutants containing permutations of the internal four (M2-M5) out of six modules. Globular proteins can also be subdivided into secondary structure units based on the extended...

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PMID: 10064693
DOI: 10.1006/jmbi.1998.2558

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