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Article

Confirmation of the hierarchical folding of RNase H: a protein engineering study.

Nature structural biology - 1 Sept 1999

Raschke T M, Kho J, Marqusee S

Abstract excerpt

The kinetic intermediate of RNase H is structured in a core region of the protein. To probe the role of this intermediate in the folding of RNase H, the folding kinetics of mutant proteins with altered native state stabilities were investigated. Mutations within the folding core destabilize the kinetic intermediate and slow refolding in a manner consistent with an obligatory intermediate model. Mutations outside...

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Identifiers

PMID: 10467093
DOI: 10.1038/12277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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