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Article

The structure of the major transition state for folding of an FF domain from experiment and simulation.

Journal of molecular biology - 8 Jul 2005

Jemth Per, Day Ryan, Gianni Stefano, Khan Faaizah, Allen Mark, Daggett Valerie, Fersht Alan R

Abstract excerpt

We have analysed the transition state of folding of the four-helix FF domain from HYPA/FBP11 by high-resolution experiment and simulation as part of a continuing effort to understand the principles of folding and the refinement of predictive methods. The major transition state for folding was subjected to a Phi-value analysis utilising 50 mutants. The transition state contained a nucleus for folding centred...

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PMID: 15935381
DOI: 10.1016/j.jmb.2005.04.067

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