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Article

Foldability, enzymatic activity, and interacting ability of barnase mutants obtained by permutation of secondary structure units.

Biochemistry - 8 Jun 2004

Tsuji Toru, Yanagawa Hiroshi

Abstract excerpt

Barnase, a well-characterized ribonuclease, has been decomposed into six modules (M1-M6) or secondary structure units (S1-S6). We have studied the foldability and activity of the barnase mutants obtained by permutation of the four internal modules (M2-M5) or secondary structure units (S2-S5) to investigate whether permutation of these building blocks is a useful way to create foldable and/or functional proteins....

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Identifiers

PMID: 15170334
DOI: 10.1021/bi049882v

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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