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Article

Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.

The EMBO journal - 23 Feb 2005

Vinciguerra Patrizia, Iglesias Nahid, Camblong Jurgi, Zenklusen Daniel, Stutz Françoise

Abstract excerpt

The mRNA export adaptor Yra1p/REF contributes to nascent mRNP assembly and recruitment of the export receptor Mex67p. yra1 mutants exhibit mRNA export defects and a decrease in LacZ reporter and certain endogenous transcripts. The loss of Mlp1p/Mlp2p, two TPR-like proteins attached to nuclear pores, rescues LacZ mRNA levels and increases their appearance in the cytoplasm, without restoring bulk poly(A)+ RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15692572
DOI: 10.1038/sj.emboj.7600527
PMCID: PMC549612

Genes

TPR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.PMID 15692572Read ↗

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export.Semantic proximity Read ↗

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.Semantic proximity Read ↗

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA exportSemantic proximity Read ↗

The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.Semantic proximity Read ↗

Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery.Semantic proximity Read ↗

Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.Semantic proximity Read ↗

A genetic screen in Saccharomyces cerevisiae identifies new genes that interact with mex67-5, a temperature-sensitive allele of the gene encoding the mRNA export receptor.Semantic proximity Read ↗

Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor.Semantic proximity Read ↗

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.Semantic proximity Read ↗

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.Semantic proximity Read ↗

Following temperature stress, export of heat shock mRNA occurs efficiently in cells with mutations in genes normally important for mRNA export.Semantic proximity Read ↗

Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism.Semantic proximity Read ↗

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