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Article

Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery.

Nature genetics - 1 Feb 2003

Hieronymus Haley, Silver Pamela A

Abstract excerpt

Nuclear export of mRNA is mediated by a complex machinery of RNA-binding proteins that recognizes and routes mRNAs through a messenger ribonucleoprotein (mRNP) network. The full spectrum of mRNA cargoes for any dedicated mRNA export factor is unknown. We identified the mRNAs that bind two conserved yeast mRNA export factors, Yra1 (refs. 1-5) and Mex67 (refs. 6,7), on a genome-wide scale and determined their level...

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PMID: 12524544
DOI: 10.1038/ng1080

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genome-wide analysis of RNA-protein interactions illustrates specificity of the mRNA export machinery.PMID 12524544Read ↗

Yra1p, a conserved nuclear RNA-binding protein, interacts directly with Mex67p and is required for mRNA export.Semantic proximity Read ↗

Stable mRNP formation and export require cotranscriptional recruitment of the mRNA export factors Yra1p and Sub2p by Hpr1p.Semantic proximity Read ↗

A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAs.Semantic proximity Read ↗

An elevated level of the mRNA exporter Mex67-Mtr2 in nuclear mRNPs impairs nuclear mRNA exportSemantic proximity Read ↗

Expression of the essential mRNA export factor Yra1p is autoregulated by a splicing-dependent mechanism.Semantic proximity Read ↗

Perinuclear Mlp proteins downregulate gene expression in response to a defect in mRNA export.Semantic proximity Read ↗

Genome-wide screen uncovers novel pathways for tRNA processing and nuclear-cytoplasmic dynamics.Semantic proximity Read ↗

Messenger RNAs are recruited for nuclear export during transcription.Semantic proximity Read ↗

A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport.Semantic proximity Read ↗

A molecular switch orchestrates the nuclear export of human messenger RNASemantic proximity Read ↗

Splicing factor Sub2p is required for nuclear mRNA export through its interaction with Yra1p.Semantic proximity Read ↗

Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.Semantic proximity Read ↗

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