Article
Insights into mRNP biogenesis provided by new genetic interactions among export and transcription factors.
BMC genetics - 10 Sept 2012
Estruch Francisco, Hodge Christine, Gómez-Navarro Natalia, Peiró-Chova Lorena, Heath Catherine V, Cole Charles N
Abstract excerpt
BACKGROUND: The various steps of mRNP biogenesis (transcription, processing and export) are interconnected. It has been shown that the transcription machinery plays a pivotal role in mRNP assembly, since several mRNA export factors are recruited during transcription and physically interact with components of the transcription machinery. Although the shuttling DEAD-box protein Dbp5p is concentrated on the...
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