Article
Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.
The EMBO journal - 2 Jun 1997
Segref A, Sharma K, Doye V, Hellwig A, Huber J, Lührmann R, Hurt E
Abstract excerpt
An essential cellular factor for nuclear mRNA export called Mex67p which has homologous proteins in human and Caenorhabditis elegans was identified through its genetic interaction with nucleoporin Nup85p. In the thermosensitive mex67-5 mutant, poly(A)+ RNA accumulates in intranuclear foci shortly...
Topics
- Amino Acid Sequence
- Biological Transport
- Cell Compartmentation
- Cell Nucleus
- Cloning, Molecular
- Cytoplasm
- DNA Mutational Analysis
- Molecular Sequence Data
- Mutation
- Nuclear Envelope
- Nuclear Pore Complex Proteins
- Nuclear Proteins
- Nucleocytoplasmic Transport Proteins
- Polymerase Chain Reaction
- Porins
- Protein Binding
- RNA, Messenger
- RNA-Binding Proteins