Article
The DEAD-box protein Dbp5p is required to dissociate Mex67p from exported mRNPs at the nuclear rim.
Molecular cell - 23 Nov 2005
Lund Mette K, Guthrie Christine
Abstract excerpt
Eukaryotic mRNAs are exported from the nucleus to the cytoplasm as complex mRNA-protein particles (mRNPs), and translocation through the nuclear pore complex (NPC) is accompanied by extensive structural changes of the mRNP. We have tested the hypothesis that the DEAD-box ATPase Dbp5p is required for such an mRNP rearrangement. In dbp5 mutant cells, the mRNA export receptor Mex67p accumulates on mRNA. This...
Topics
- Active Transport, Cell Nucleus
- Cell Nucleus
- DEAD-box RNA Helicases
- Mutation
- Nuclear Proteins
- Nucleocytoplasmic Transport Proteins
- RNA Helicases
- RNA, Messenger
- RNA-Binding Proteins
- Ribonucleoproteins
- Saccharomyces cerevisiae