Article
Functional interaction between APOE4 and LDL receptor isoforms in Alzheimer's disease.
Journal of medical genetics - 1 Feb 2005
Cheng D, Huang R, Lanham I S, Cathcart H M, Howard M, Corder E H, Poduslo S E
Abstract excerpt
BACKGROUND: Multiple genes have been provisionally associated with Alzheimer's disease, including the coding polymorphisms in exons 8 and 13 in the low density lipoprotein receptor gene (LDLR), situated on chromosome 19p13.2. METHODS: The sample groups consisted of 180 AD patients and 141 control spouses. We carried out genotyping of LDLR8 and LDLR13. RESULTS: The LDLR8 GG genotype was common, found in 84% of the...
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