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Article

Epistatic interaction of apolipoprotein E and lipolysis-stimulated lipoprotein receptor genetic variants is associated with Alzheimer's disease.

Neurobiology of aging - 1 Sept 2018

Xie Ting, Akbar Samina, Stathopoulou Maria G, Oster Thierry, Masson Christine, Yen Frances T, Visvikis-Siest Sophie

Abstract excerpt

The ε4 allele of the apolipoprotein E (APOE) gene common polymorphism is the strongest genetic risk factor for Alzheimer's disease (AD). Human APOE gene is located on chromosome 19q13.1, a region linked to AD that also includes the LSR gene, which encodes the lipolysis-stimulated lipoprotein receptor (LSR). As an APOE receptor, LSR is involved in the regulation of lipid homeostasis in both periphery and brain....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29858039
DOI: 10.1016/j.neurobiolaging.2018.04.013

Genes

APOE
LSR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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