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Article

Genetic interaction between tau and the apolipoprotein E receptor LRP1 Increases Alzheimer's disease risk.

Dementia and geriatric cognitive disorders - 1 Jan 2009

Vázquez-Higuera José Luis, Mateo Ignacio, Sánchez-Juan Pascual, Rodríguez-Rodríguez Eloy, Pozueta Ana, Infante Jon, Berciano José, Combarros Onofre

Abstract excerpt

Abnormal tau hyperphosphorylation is one of the central events in the development of neurofibrillary tangles (NFTs) in Alzheimer's disease (AD), and phosphorylation of tau is accelerated by the increase in the level of neuronal cholesterol. Apolipoprotein E (APOE) promotes the neuronal uptake of...

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Source

Identifiers

PMID: 19684401
DOI: 10.1159/000234913

Genes

APOE
LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19684401-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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