Article
Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population.
Neuroscience letters - 7 Feb 1997
Lendon C L, Talbot C J, Craddock N J, Han S W, Wragg M, Morris J C, Goate A M
Abstract excerpt
The epsilon 4 allele of the apolipoprotein E gene (ApoE) is associated with an increased risk for sporadic and some familial forms of Alzheimer's disease (AD) but the precise mechanism of pathogenesis is unknown. ApoE is a ligand for at least three receptors in the central nervous system, low density lipoprotein receptor (LDL-R), very low density lipoprotein receptor VLDL-R and low density lipoprotein-like...
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