Article
Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population.
Neuroscience letters - 7 Feb 1997
Lendon C L, Talbot C J, Craddock N J, Han S W, Wragg M, Morris J C, Goate A M
Abstract excerpt
The epsilon 4 allele of the apolipoprotein E gene (ApoE) is associated with an increased risk for sporadic and some familial forms of Alzheimer's disease (AD) but the precise mechanism of pathogenesis is unknown. ApoE is a ligand for at least three receptors in the central nervous system, low den...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoproteins
- Case-Control Studies
- Chi-Square Distribution
- Female
- Gene Frequency
- Genotype
- Humans
- Low Density Lipoprotein Receptor-Related Protein-1
- Male
- Middle Aged
- Periodicity
- Receptors, Lipoprotein
- White People