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Article

Lack of interaction between LRP1 and A2M polymorphisms for the risk of Alzheimer disease.

Neuroscience letters - 27 Sept 2010

Bruno Elisa, Quattrocchi Graziella, Nicoletti Alessandra, Le Pira Francesco, Maci Tiziana, Mostile Giovanni, Andreoli Virginia, Quattrone Aldo, Zappia Mario

Abstract excerpt

Alzheimer disease (AD) has a heterogeneous aetiology, involving genetic and environmental factors. Low-density lipoprotein receptor-related protein 1 (LRP1), alpha-2-macroglobulin (A2M) and apolipoprotein E (APOE) are involved in molecular pathways leading to beta-amyloid deposition. Three polymorphic sites in these genes (APOE-epsilon 2/epsilon 3/epsilon 4, A2M-Ile/Val and LRP1-C/T) have been associated with AD,...

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Source

Identifiers

PMID: 20637261
DOI: 10.1016/j.neulet.2010.07.012

Genes

LRP1
APOE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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