Article
Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions.
Neuron - 1 Oct 1993
Rebeck G W, Reiter J S, Strickland D K, Hyman B T
Abstract excerpt
An increased prevalence of apolipoprotein E (ApoE) epsilon 4 allele exists in late onset familial Alzheimer's disease. We found, in sporadic Alzheimer's disease, that 62% of patients possessed an ApoE-epsilon 4 allele, compared with 20% of controls. ApoE-epsilon 4/4 patients had more senile plaqu...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Apolipoproteins E
- Genetic Variation
- Genotype
- Hippocampus
- Humans
- Immunohistochemistry
- Low Density Lipoprotein Receptor-Related Protein-1
- Middle Aged
- Receptors, Immunologic
- Receptors, LDL
- Reference Values
- Temporal Lobe