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Article

Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia.

Neurobiology of aging - 1 Feb 2009

Helbecque Nicole, Cottel Dominique, Amouyel Philippe

Abstract excerpt

The sole known genetic risk factor for sporadic Alzheimer's disease (AD) is the gene encoding apolipoprotein E (APOE), but the underlying mechanism is still under debate. One hypothesis relies on an interaction between APOE and its receptors. Previous studies have shown association of LDL receptor-related protein (LRP1) with AD and we previously reported a modulation by LRP1 of the risk of AD conferred by the...

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Source

Identifiers

PMID: 17614163
DOI: 10.1016/j.neurobiolaging.2007.05.024

Genes

APOE
LRP1
LRP8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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