Article
Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease.
Neurology - 1 Jul 1997
Kang D E, Saitoh T, Chen X, Xia Y, Masliah E, Hansen L A, Thomas R G, Thal L J, Katzman R
Abstract excerpt
The presence of the APOE epsilon 4 allele encoding apolipoprotein E4 (apoE4) is the major genetic risk factor for late-onset Alzheimer's disease (AD). However, the molecular and cellular mechanisms by which APOE epsilon 4 renders AD risk are unclear. In this report, we present genetic evidence th...
Topics
- Age of Onset
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Female
- Genotype
- Humans
- Low Density Lipoprotein Receptor-Related Protein-1
- Male
- Receptors, LDL
- Receptors, Lipoprotein
- Risk Factors