Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2.

The American journal of pathology - 1 Feb 2005

Müller-Decker Karin, Berger Irina, Ackermann Karin, Ehemann Volker, Zoubova Svetlana, Aulmann Sebastian, Pyerin Walter, Fürstenberger Gerhard

Abstract excerpt

Expression and pharmacological studies support a contribution of cyclooxygenase (COX)-2 to mammary gland tumorigenesis. In a recent transgenic study, mouse mammary tumor virus promoter-driven COX-2 expression in mouse mammary glands was shown to result in alveolar hyperplasia, dysplasia, and carcinomas after multiple rounds of pregnancy and lactation. In the study presented here, the effects of constitutive COX-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Caspase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase 2

Share to Keratin-5

Share to Keratins

Share to Ki-67 Antigen

Share to Mammary Glands, Animal

Share to Prostaglandin-Endoperoxide Synthases

Source

Open in PubMed Open full text

Identifiers

PMID: 15681840
DOI: 10.1016/S0002-9440(10)62279-1
PMCID: PMC1602328

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cystic duct dilatations and proliferative epithelial lesions in mouse mammary glands upon keratin 5 promoter-driven overexpression of cyclooxygenase-2.PMID 15681840Read ↗

Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression.Semantic proximity Read ↗

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin.Semantic proximity Read ↗

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.Semantic proximity Read ↗

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland developmentSemantic proximity Read ↗

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.Semantic proximity Read ↗

Histologically normal human mammary epithelia with silenced p16INK4a overexpress COX-2, promoting a premalignant programSemantic proximity Read ↗

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.Semantic proximity Read ↗

Epidermal growth factor-like growth factors. I. Breast malignancies and other epithelial proliferations in transgenic mice.Semantic proximity Read ↗

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.Semantic proximity Read ↗

COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.Semantic proximity Read ↗

Conditional regulation of cyclooxygenase-2 in tracheobronchial epithelial cells modulates pulmonary immunity.Semantic proximity Read ↗

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.