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Article

Cyclooxygenase‐2 modulates cellular growth and promotes tumorigenesis

1 Jul 2003

Abstract excerpt

Cyclooxygenase (COX)-2 and the prostaglandins resulting from its enzymatic activity have been shown to play a role in modulating cell growth and development of human neoplasia. Evidence includes a direct relationship between COX-2 expression and cancer incidence in humans and animal models, increased tumorigenesis after genetic manipulation of COX-2, and significant anti-tumor properties of non-steroidal...

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PMID: 14594546
DOI: 10.1111/j.1582-4934.2003.tb00222.x

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