Article
Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jun 2001
Neufang G, Furstenberger G, Heidt M, Marks F, Müller-Decker K
Abstract excerpt
In prostanoid biosynthesis, the first two steps are catalyzed by cyclooxygenases (COX). In mice and humans, deregulated expression of COX-2, but not of COX-1, is characteristic of epithelial tumors, including squamous cell carcinomas of skin. To explore the function of COX-2 in epidermis, a keratin 5 promoter was used to direct COX-2 expression to the basal cells of interfollicular epidermis and the pilosebaceous...
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