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Article

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 17 Sept 2002

Muller-Decker Karin, Neufang Gitta, Berger Irina, Neumann Melanie, Marks Friedrich, Furstenberger Gerhard

Abstract excerpt

Genetic and pharmacological evidence suggests that overexpression of cyclooxygenase-2 (COX-2) is critical for epithelial carcinogenesis and provides a major target for cancer chemoprevention by nonsteroidal antiinflammatory drugs. Transgenic mouse lines with keratin 5 promoter-driven COX-2 overexpression in basal epidermal cells exhibit a preneoplastic skin phenotype. As shown here, this phenotype depends on the...

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Identifiers

PMID: 12221288
DOI: 10.1073/pnas.192323799
PMCID: PMC129471

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.PMID 12221288Read ↗

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