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Article

COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.

Stem cells (Dayton, Ohio) - 1 Sept 2016

Majumder Mousumi, Xin Xiping, Liu Ling, Tutunea-Fatan Elena, Rodriguez-Torres Mauricio, Vincent Krista, Postovit Lynne-Marie, Hess David, Lala Peeyush K

Abstract excerpt

Cancer stem-like cells (SLC) resist conventional therapies, necessitating searches for SLC-specific targets. We established that cyclo-oxygenase(COX)-2 expression promotes human breast cancer progression by activation of the prostaglandin(PG)E-2 receptor EP4. Present study revealed that COX-2 induces SLCs by EP4-mediated NOTCH/WNT signaling. Ectopic COX-2 over-expression in MCF-7 and SKBR-3 cell lines resulted...

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Identifiers

PMID: 27301070
DOI: 10.1002/stem.2426

Genes

GUSB
NANOG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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COX-2 Induces Breast Cancer Stem Cells via EP4/PI3K/AKT/NOTCH/WNT Axis.PMID 27301070Read ↗

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