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Article

Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression.

Neoplasia (New York, N.Y.) - 1 Aug 2008

Colby Jennifer Kl, Klein Russell D, McArthur Mark J, Conti Claudio J, Kiguchi Kaoru, Kawamoto Toru, Riggs Penny K, Pavone Amy I, Sawicki Janet, Fischer Susan M

Abstract excerpt

Cyclooxygenase-2 (COX-2) overexpression is an established factor linking chronic inflammation with metaplastic and neoplastic change in various tissues. We generated transgenic mice (BK5.COX-2) in which elevation of COX-2 and its effectors trigger a metaplasia-dysplasia sequence in exocrine pancreas. Histologic evaluation revealed a chronic pancreatitis-like state characterized by acinar-to-ductal metaplasia and...

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Identifiers

PMID: 18670639
DOI: 10.1593/neo.08330
PMCID: PMC2481568

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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