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STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development

10 Jun 2017

Abstract excerpt

Macrophages are required for proper mammary gland development and maintaining tissue homeostasis. However, the mechanisms by which macrophages regulate this process remain unclear. Here, we identify STAT5 as an important regulator of macrophage function in the developing mammary gland. Analysis of mammary glands from mice with STAT5-deficient macrophages demonstrates delayed ductal elongation, enhanced ductal...

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PMID: 28606561
DOI: 10.1016/j.ydbio.2017.06.007

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