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Article

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.

Aging - 7 Oct 2016

Kim Joohwee, Vaish Vivek, Feng Mingxiao, Field Kevin, Chatzistamou Ioulia, Shim Minsub

Abstract excerpt

Cyclooxygenase (COX) is a key enzyme in the biosynthesis of prostanoids, lipid signaling molecules that regulate various physiological processes. COX2, one of the isoforms of COX, is highly inducible in response to a wide variety of cellular and environmental stresses. Increased COX2 expression is thought to play a role in the pathogenesis of many age-related diseases. COX2 expression is also reported to be...

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Identifiers

PMID: 27750221
DOI: 10.18632/aging.101060
PMCID: PMC5115895

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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