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Article

Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.

Biochemical pharmacology - 15 Oct 1999

Langenbach R, Loftin C, Lee C, Tiano H

Abstract excerpt

The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms. In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female...

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Source

Identifiers

PMID: 10487525
DOI: 10.1016/s0006-2952(99)00158-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cyclooxygenase knockout mice: models for elucidating isoform-specific functions.PMID 10487525Read ↗

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Distinct functions of COX-1 and COX-2.Semantic proximity Read ↗

Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.Semantic proximity Read ↗

Conditional knockout mouse for tissue-specific disruption of the cyclooxygenase-2 (Cox-2) geneSemantic proximity Read ↗

Rescue of Female Infertility from the Loss of Cyclooxygenase-2 by Compensatory Up-regulation of Cyclooxygenase-1 Is a Function of Genetic MakeupSemantic proximity Read ↗

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