Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.

Cancer research - 1 May 2002

Bol David K, Rowley R Bruce, Ho Ching-Ping, Pilz Brigette, Dell Janet, Swerdel Mavis, Kiguchi Kaoru, Muga Stephanie, Klein Russell, Fischer Susan M

Abstract excerpt

Significant evidence has accumulated suggesting that the inducible form of cyclooxygenase (COX-2), a central enzyme in the prostaglandin biosynthetic pathway, plays an important role in tumor development. To better understand the role of COX-2 in tumorigenesis, we generated transgenic mice that o...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Alopecia
Share to Cyclooxygenase 2 Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclooxygenase Inhibitors

Share to Dinoprostone

Share to Hair Follicle

Share to Mice, Inbred ICR

Share to Prostaglandin-Endoperoxide Synthases

Source

Identifiers

PMID: 11980643

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11980643-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.PMID 11980643Read ↗

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.Semantic proximity Read ↗

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin.Semantic proximity Read ↗

Transgenic expression of cyclooxygenase-2 (COX2) causes premature aging phenotypes in mice.Semantic proximity Read ↗

Mouse skin as a model for cancer chemoprevention by nonsteroidal anti-inflammatory drugs.Semantic proximity Read ↗

Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.Semantic proximity Read ↗

New insights into the functions of Cox-2 in skin and esophageal malignanciesSemantic proximity Read ↗

Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity.Semantic proximity Read ↗

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Semantic proximity Read ↗

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.Semantic proximity Read ↗

A role for cyclooxygenase‐2 in ultraviolet light‐induced skin carcinogenesisSemantic proximity Read ↗

Thrombospondin-2 overexpression in the skin of transgenic mice reduces the susceptibility to chemically induced multistep skin carcinogenesis.Semantic proximity Read ↗

Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.