Article
PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.
The Journal of clinical investigation - 1 Sept 2003
Matsumoto Michihiro, Ogawa Wataru, Akimoto Kazunori, Inoue Hiroshi, Miyake Kazuaki, Furukawa Kensuke, Hayashi Yoshitake, Iguchi Haruhisa, Matsuki Yasushi, Hiramatsu Ryuji, Shimano Hitoshi, Yamada Nobuhiro, Ohno Shigeo, Kasuga Masato, Noda Tetsuo
Abstract excerpt
PKClambda is implicated as a downstream effector of PI3K in insulin action. We show here that mice that lack PKClambda specifically in the liver (L-lambdaKO mice), produced with the use of the Cre-loxP system, exhibit increased insulin sensitivity as well as a decreased triglyceride content and reduced expression of the sterol regulatory element-binding protein-1c (SREBP-1c) gene in the liver. Induction of the...
Topics
- Animals
- Blood Glucose
- CCAAT-Enhancer-Binding Proteins
- Cells, Cultured
- DNA-Binding Proteins
- Gene Expression Regulation
- Hepatocytes
- Humans
- Insulin