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Article

Transgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetes.

Endocrinology - 1 Jun 2009

Villafuerte Betty C, Barati Michelle T, Song Ying, Moore Joseph P, Epstein Paul N, Portillo Jessica

Abstract excerpt

Recent evidence supports the idea that insulin signaling through the insulin receptor substrate/phosphatidyl-inositol 3-kinase/Akt pathway is involved in the maintenance of beta-cell mass and function. We previously identified the insulin-response element binding protein-1 (IRE-BP1) as an effecto...

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Identifiers

PMID: 19213832
DOI: 10.1210/en.2008-1294
PMCID: PMC2689803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19213832-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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