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Crtc1 Deficiency Causes Obesity Potentially via Regulating PPARγ Pathway in White Adipose

12 Apr 2021

Abstract excerpt

Obesity is characterized by excessive fat accumulation and associated with glucose and lipid metabolism disorders. Crtc1, a transcription cofactor regulating CREB activity, has been involved in the pathogenesis of metabolic syndrome; however, the underlying mechanism remains under debate. Here we generated a Crtc1–/– mouse line using the CRISPR/Cas9 system. Under normal feeding conditions, Crtc1–/– mice exhibited...

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PMID: 33912553
DOI: 10.3389/fcell.2021.602529

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