Article
Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy.
Genes & development - 15 Oct 1998
Shimomura I, Hammer R E, Richardson J A, Ikemoto S, Bashmakov Y, Goldstein J L, Brown M S
Abstract excerpt
Overexpression of the nuclear form of sterol regulatory element-binding protein-1c (nSREBP-1c/ADD1) in cultured 3T3-L1 preadipocytes was shown previously to promote adipocyte differentiation. Here, we produced transgenic mice that overexpress nSREBP-1c in adipose tissue under the control of the a...
Topics
- Adipose Tissue
- Animals
- Animals, Newborn
- Blood Glucose
- CCAAT-Enhancer-Binding Proteins
- Cell Differentiation
- DNA-Binding Proteins
- Diabetes Mellitus, Experimental
- Diabetes Mellitus, Lipoatrophic
- Disease Models, Animal
- Female
- Insulin
- Insulin Resistance