Article
Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.
PloS one - 1 Jan 2012
Knebel Birgit, Haas Jutta, Hartwig Sonja, Jacob Sylvia, Köllmer Cornelia, Nitzgen Ulrike, Muller-Wieland Dirk, Kotzka Jorg
Abstract excerpt
The pathogenesis of fatty liver is not understood in detail, but lipid overflow as well as de novo lipogenesis (DNL) seem to be the key points of hepatocyte accumulation of lipids. One key transcription factor in DNL is sterol regulatory element-binding protein (SREBP)-1c. We generated mice with liver-specific over-expression of mature human SREBP-1c under control of the albumin promoter and a liver-specific...
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