Article

Loss of <i>RREB1</i> reduces adipogenesis and improves insulin sensitivity in mouse and human adipocytes

2024-07-31

Abstract excerpt

There are multiple independent genetic signals at the Ras-responsive element binding protein 1 ( RREB1 ) locus associated with type 2 diabetes risk, fasting glucose, ectopic fat, height, and bone mineral density. We have previously shown that loss of RREB1 in pancreatic beta cells reduces insulin content and impairs islet cell development and function. However, RREB1 is a widely expressed transcription factor a...

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Identifiers and source

Literature Corpus work: fdd69b23-9632-5468-b2f7-86fa197ba9cb
DOI: 10.1101/2024.07.30.605923

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