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Article

Essential role of IkappaB kinase alpha in the constitutive processing of NF-kappaB2 p100.

The Journal of biological chemistry - 18 Mar 2005

Qing Guoliang, Xiao Gutian

Abstract excerpt

Processing of NF-kappaB2 precursor protein p100 to generate p52 is tightly controlled, which is important for proper function of NF-kappaB. Accordingly, constitutive processing of p100, caused by the loss of its C-terminal processing inhibitory domain due to nfkappab2 gene rearrangements, is associated with the development of various lymphomas and leukemia. In contrast to the physiological processing of p100...

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PMID: 15677466
DOI: 10.1074/jbc.C400502200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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