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Article

Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation.

Science signaling - 25 May 2010

Razani Bahram, Zarnegar Brian, Ytterberg A Jimmy, Shiba Travis, Dempsey Paul W, Ware Carl F, Loo Joseph A, Cheng Genhong

Abstract excerpt

Canonical and noncanonical nuclear factor kappaB (NF-kappaB) signaling are the two basic pathways responsible for the release of NF-kappaB dimers from their inhibitors. Enhanced NF-kappaB signaling leads to inflammatory and proliferative diseases; thus, inhibitory pathways that limit its activity are critical. Whereas multiple negative feedback mechanisms control canonical NF-kappaB signaling, none has been...

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Identifiers

PMID: 20501937
DOI: 10.1126/scisignal.2000778
PMCID: PMC2913610

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