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Article

Shared pathways of IkappaB kinase-induced SCF(betaTrCP)-mediated ubiquitination and degradation for the NF-kappaB precursor p105 and IkappaBalpha.

Molecular and cellular biology - 1 Feb 2001

Heissmeyer V, Krappmann D, Hatada E N, Scheidereit C

Abstract excerpt

p105 (NFKB1) acts in a dual way as a cytoplasmic IkappaB molecule and as the source of the NF-kappaB p50 subunit upon processing. p105 can form various heterodimers with other NF-kappaB subunits, including its own processing product, p50, and these complexes are signal responsive. Signaling through the IkappaB kinase (IKK) complex invokes p105 degradation and p50 homodimer formation, involving p105...

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Share to I-kappa B Kinase
Share to I-kappa B Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to NF-kappa B p50 Subunit

Share to NF-KappaB Inhibitor alpha

Share to Peptide Synthases

Share to Protein Precursors

Share to SKP Cullin F-Box Protein Ligases

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Source

Open in PubMed Open full text

Identifiers

PMID: 11158290
DOI: 10.1128/MCB.21.4.1024-1035.2001
PMCID: PMC99557

Genes

NFKB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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