Article
Identification and characterization of p100HB, a new mutant form of p100/NF-kappa B2.
Biochemical and biophysical research communications - 5 Sept 2003
Derudder Emmanuel, Laferté Arnaud, Ferreira Valérie, Mishal Zohair, Baud Véronique, Tarantino Nadine, Körner Marie
Abstract excerpt
P100, which is encoded by NF-kappa B2, inhibits Rel dimers. It can also be processed into p52, one of the DNA binding sub-units of NF-kappa B/Rel factors. Several p100 C-terminal truncations that result from gene rearrangements are associated with lymphomagenesis. Here, we characterized a new p100 mutant that we termed p100HB. It originates from a point-mutation that generates a premature stop-codon, and thus the...
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