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Article

Essential role of IkappaB kinase alpha in thymic organogenesis required for the establishment of self-tolerance.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2006

Kinoshita Dan, Hirota Fumiko, Kaisho Tsuneyasu, Kasai Michiyuki, Izumi Keisuke, Bando Yoshimi, Mouri Yasuhiro, Matsushima Akemi, Niki Shino, Han Hongwei, Oshikawa Kiyotaka, Kuroda Noriyuki, Maegawa Masahiko, Irahara Minoru, Takeda Kiyoshi, Akira Shizuo, Matsumoto Mitsuru

Abstract excerpt

IkappaB kinase (IKK) alpha exhibits diverse biological activities through protein kinase-dependent and -independent functions, the former mediated predominantly through a noncanonical NF-kappaB activation pathway. The in vivo function of IKKalpha, however, still remains elusive. Because a natural strain of mice with mutant NF-kappaB-inducing kinase (NIK) manifests autoimmunity as a result of disorganized thymic...

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Identifiers

PMID: 16547234
DOI: 10.4049/jimmunol.176.7.3995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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