Article
Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.
The Journal of experimental medicine - 6 Oct 1997
Ishikawa H, Carrasco D, Claudio E, Ryseck R P, Bravo R
Abstract excerpt
The nfkb2 gene encodes the p100 precursor which produces the p52 protein after proteolytic cleavage of its COOH-terminal domain. Although the p52 product can act as an alternative subunit of NF-kappaB, the p100 precursor is believed to function as an inhibitor of Rel/NF-kappaB activity by cytopla...
Topics
- Animals
- Ankyrins
- Blotting, Western
- Cell Division
- Cytokines
- DNA Primers
- DNA-Binding Proteins
- Dimerization
- Flow Cytometry
- Gene Targeting
- Hyperplasia
- I-kappa B Proteins
- In Situ Hybridization
- Lymphocyte Activation
- Mice
- Mice, Knockout
- NF-kappa B
- NF-kappa B p52 Subunit