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Article

Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.

The Journal of experimental medicine - 6 Oct 1997

Ishikawa H, Carrasco D, Claudio E, Ryseck R P, Bravo R

Abstract excerpt

The nfkb2 gene encodes the p100 precursor which produces the p52 protein after proteolytic cleavage of its COOH-terminal domain. Although the p52 product can act as an alternative subunit of NF-kappaB, the p100 precursor is believed to function as an inhibitor of Rel/NF-kappaB activity by cytoplasmic retention of Rel/NF-kappaB complexes, like other members of the IkappaB family. However, the physiological...

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Identifiers

PMID: 9314550
DOI: 10.1084/jem.186.7.999
PMCID: PMC2199059

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Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-kappaB2.PMID 9314550Read ↗

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