Article
Endoproteolytic processing of C-terminally truncated NF-kappaB2 precursors at kappaB-containing promoters.
Proceedings of the National Academy of Sciences of the United States of America - 27 Mar 2007
Qing Guoliang, Qu Zhaoxia, Xiao Gutian
Abstract excerpt
The C-terminal, partially truncated forms of the NF-kappaB2/p52 precursor p100, p100DeltaCs, manifest constitutive processing and oncogenic ability, although the responsible mechanisms remain unknown. Here, we report that p100DeltaCs are specifically processed in association with binding to promoter DNA-containing kappaB sites. In the nucleus, p100DeltaCs bind to the kappaB promoter DNA and subsequently recruit...
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