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Article

Structure-function analysis of human transforming growth factor-alpha by site-directed mutagenesis.

The Biochemical journal - 1 Apr 1992

Feild J A, Reid R H, Rieman D J, Kline T P, Sathe G, Greig R G, Anzano M A

Abstract excerpt

Site-directed mutants of transforming growth factor-alpha (TGF-alpha) were expressed in an Escherichia coli outer membrane protein A (ompA) expression/secretion vector under the transcriptional control of the lambda PL promoter. TGF-alpha mutant proteins were isolated from cell pellets using alka...

Topics

Amino Acid Sequence
Gene Expression
Humans
Macromolecular Substances
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Protein Conformation
Sequence Homology, Nucleic Acid
Structure-Activity Relationship
Transforming Growth Factor alpha

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Identifiers

PMID: 1567383
DOI: 10.1042/bj2830091
PMCID: PMC1130998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1567383-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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