Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human thrombopoietin structure-function relationships: identification of functionally important residues.

The Biochemical journal - 1 Aug 1998

Jagerschmidt A, Fleury V, Anger-Leroy M, Thomas C, Agnel M, O'brien D P

Abstract excerpt

Thrombopoietin (TPO) is a haematopoietic growth factor responsible for megakaryocyte progenitor proliferation and differentiation. It belongs to the four-helix-bundle cytokine family and exerts its biological effects through binding to a specific receptor, c-Mpl. With the use of site-directed mutagenesis we have generated 20 TPO mutants. Each of the TPO mutants was produced in a eukaryotic expression system and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites
Share to Cell Division

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Molecular Sequence Data

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Sequence Homology, Amino Acid

Share to Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 9677334
DOI: 10.1042/bj3330729
PMCID: PMC1219638

Genes

TPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human thrombopoietin structure-function relationships: identification of functionally important residues.PMID 9677334Read ↗

Mutational analysis of thrombopoietin for identification of receptor and neutralizing antibody sites.Semantic proximity Read ↗

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet ProductionSemantic proximity Read ↗

Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.Semantic proximity Read ↗

Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure.Semantic proximity Read ↗

A novel nonpeptidyl human c-Mpl activator stimulates human megakaryopoiesis and thrombopoiesis.Semantic proximity Read ↗

Genomic structure, chromosomal localization, and conserved alternative splice forms of thrombopoietinSemantic proximity Read ↗

Familial Essential Thrombocythemia Associated With One-Base Deletion in the 5′-Untranslated Region of theThrombopoietin GeneSemantic proximity Read ↗

Structural basis of MPL activation by thrombopoietinSemantic proximity Read ↗

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.Semantic proximity Read ↗

MplK, a natural variant of the thrombopoietin receptor with a truncated cytoplasmic domain, binds thrombopoietin but does not interfere with thrombopoietin-mediated cell growth.Semantic proximity Read ↗

Site-directed mutagenesis of monocyte chemoattractant protein-1 identifies two regions of the polypeptide essential for biological activitySemantic proximity Read ↗

Characterization of the truncated thrombopoietin variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.