Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: general properties and epitope analysis.

doi:10.1016/0022-2836(90)90367-U

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: general properties and epitope analysis.

Journal of molecular biology - 20 Jan 1990

Tavernier J, Marmenout A, Bauden R, Hauquier G, Van Ostade X, Fiers W

Abstract excerpt

To analyse the structure-function relationship of tumour necrosis factor (TNF), a set of in-frame chimeric genes was constructed by coupling appropriate segments of the human and mouse TNF coding regions. Under control of the bacteriophage lambda inducible PL promoter high level expression of these chimeric genes was obtained in Escherichia coli. Although both human and mouse TNF were produced in E. coli as...

Topics

Amino Acid Sequence
Animals
Chimera
Epitopes
Genes
Genetic Variation
Humans
Mice
Models, Molecular
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neutralization Tests

Plasmids

Protein Conformation

Restriction Mapping

Structure-Activity Relationship

Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 1689779
DOI: 10.1016/0022-2836(90)90367-U

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1689779-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of the structure-function relationship of tumour necrosis factor. Human/mouse chimeric TNF proteins: general properties and epitope analysis.PMID 1689779Read ↗

Production and characterization of receptor-specific TNF muteins.Semantic proximity Read ↗

Construction and initial characterization of a mouse-human chimeric anti-TNF antibodySemantic proximity Read ↗

Structural biology of tumor necrosis factor demonstrated for undergraduates instruction by computer simulation.Semantic proximity Read ↗

The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.Semantic proximity Read ↗

Mutational analysis of structure--activity relationships in human tumor necrosis factor-alpha.Semantic proximity Read ↗

A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral ProteinsSemantic proximity Read ↗

A mutated human tumor necrosis factor-alpha improves the therapeutic index in vitro and in vivo.Semantic proximity Read ↗

Mutational analysis of human tumor necrosis factor-alpha.Semantic proximity Read ↗

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journeySemantic proximity Read ↗

An Attenuated Targeted-TNF Localizes to Tumors In Vivo and Regains Activity at the Site of Disease.Semantic proximity Read ↗

Interactions between novel tumor necrosis factor-alpha mutants and receptors on tumor and normal cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.